Brain Computing Lab
Project 1
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Causal relationship between the PFC activities and the extrastriate object signals


Vision is the process of understanding the external world using light as input. Our knowledge about object recognition in temporal pathway is systematically investigated. However, the relationship between the PFC activity and the extrastriate object signal remained unanswered. The existence of neural representation for visual information in the cognitive control brain areas and the role of PFC in sensory modulation are the main questions. Prefrontal activity enhances visual cortical representations of stimuli during covert attention; could prefrontal cortex similarly modulate mnemonic representations to aid memory maintenance? In our recent work we showed that frontotemporal coordination predicts working memory performance and its local neural signatures.


We studied the responses of inferotemporal (IT) neurons, which exhibit object-selective activity, along with Frontal Eye Field (FEF) neurons, which exhibit spatially selective activity, during the delay period of an object WM task. Unlike the spiking activity and local field potentials (LFPs) within these areas, which were poor predictors of behavioral performance, the phase-locking of IT spikes and LFPs with the beta band of FEF LFPs robustly predicted successful WM maintenance. In addition, IT neurons exhibited greater object-selective persistent activity when their spikes were locked to the phase of FEF LFPs. These results demonstrate a key role of coordination between prefrontal and temporal cortex in the successful maintenance of visual information during WM.



Mohammad-Reza Abolghasemi Dehaqani

Ehsan Rezayat

rezayat [at] ipm [dot] ir



Behrad Noudoost


Tirin Moore


Kelsey Clark


Zahra Bahmani